Palmoplantar pustulosis, often called PPP, is a rare, chronic inflammatory skin condition that affects the palms of the hands and soles of the feet.
It can cause painful pustules, redness, scaling and cracking that may make everyday activities uncomfortable or difficult.
Because PPP is uncommon and can resemble other skin conditions, understanding its symptoms and available treatment options is an important first step for people living with the condition.
What Is Palmoplantar Pustulosis?
PPP causes repeated outbreaks of small pustules on the palms, soles or both. Although these bumps may look like an infection, the pustules associated with PPP are generally considered sterile and are caused by inflammation rather than a bacterial infection.
Symptoms may improve for a period of time and then return, making PPP a recurring condition for many patients.
Common PPP Symptoms
Palmoplantar pustulosis can look different from person to person, but symptoms may include:
- Painful pustules or blister-like bumps on the palms or soles
- Red or inflamed skin
- Dry, cracked or thickened skin
- Burning or itching
- Recurring periods of flares and improvement
Because PPP affects the hands and feet, symptoms can interfere with walking, working, exercising and other everyday activities. OMRC notes that painful pustules and skin fissures can significantly affect a person’s ability to carry out normal daily activities.
Is PPP the Same as Psoriasis?
PPP has a complicated relationship with psoriasis. It is an inflammatory skin disease that may occur on its own, but some people with PPP also have plaque psoriasis. Researchers continue to study the similarities and differences between these conditions and the immune pathways involved.
This is one reason an evaluation by a dermatologist can be important when persistent symptoms appear on the palms or soles.
Why Is Clinical Research Important for PPP?
Treatment for PPP can be challenging, and researchers continue to investigate therapies that may better control the inflammation and symptoms associated with the condition. Recent research has evaluated several types of systemic and targeted therapies, while additional potential treatments continue to be studied.
Clinical trials help researchers better understand PPP, evaluate investigational treatments and gather the information needed to improve future care.
Every clinical study also depends on volunteers willing to participate.
Palmoplantar Pustulosis Research in Portland, Oregon
Oregon Medical Research Center is currently studying Palmoplantar Pustulosis in Portland, Oregon. People living with PPP who have not found lasting relief with previous treatments may qualify for a clinical research study.
Participation is voluntary, and our research team can explain the study, answer your questions and help you determine whether a current research opportunity may be appropriate for you.
If you have been diagnosed with PPP or are experiencing symptoms affecting the palms of your hands or soles of your feet, learn more about Palmoplantar Pustulosis research at Oregon Medical Research Center.
Have questions? Call (503) 245-1525.